Drug induced osteoporosis

Drug - Induced Osteoporosis

1. Apply an understanding of drug mechanisms to explain drug-induced osteoporosis and its consequences. 2. Use the diagnostic process to develop treatment and monitoring plans for drug-induced osteoporosis. 3. Assess for potential risk factors associated with druginduced osteoporosis. 4. Evaluate the epidemiologic literature to assess the absolute increase in risk of drug-induced osteoporosis a...

Drug-induced osteoporosis: mechanisms and clinical implications.

Drug-induced osteoporosis is common and has a significant impact on the prognosis of patients suffering from chronic debilitating diseases. Glucocorticoids are the drugs causing osteoporotic fractures most frequently, but osteoporosis with fractures is observed also in women treated with aromatase inhibitors for breast cancer, in men receiving anti-androgen therapy for prostate cancer, in postm...

Steroid-induced osteoporosis.

INTRODUCTION Corticosteroids have major effects on calcium metabolism, leading to accelerated osteoporosis and fracture. METHODS This review will attempt to summarise current knowledge about their effects in light of new information and important remaining questions, especially with respect to management of this common condition. RESULTS Corticosteroids affect bone through multiple pathways...

Glucocorticoid-induced Osteoporosis

Glucocorticoid induced osteoporosis.

Glucocorticoid therapy is the most common cause of secondary osteoporosis and the leading iatrogenic cause of the disease. Often, the presenting manifestation is fracture, which occurs in 30% to 50% of patients receiving long-term glucocorticoid therapy. Glucocorticoid-induced osteoporosis predominantly affects regions of the skeleton that have abundant cancellous bone such as lumbar spine and ...